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COMPARATIVE STUDY ON THE IRRITATIONPOTENTIAL OF SEVERAL PULPOTOMY AGENTS APPLIED TO CONNECTIVE TISSURES IN RATS

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Abstract

°á·Ð
1. 2%¿Í 5% glutaraldehyde ½ÇÇ豺ÀÇ °æ¿ì ¿°ÁõÁ¤µµ¿¡ Å« Â÷ÀÌ°¡ ¾ø¾ú´Ù.
2. 10% glutaraldehyde ½ÇÇ豺ÀÇ 1ÀÏ Á¶Á÷ ¼Ò°ßÀº 2%, 5% glutaraldehyde ½ÇÇ豺º¸´Ù ½É
ÇÑ ¿°Áõ¹ÝÀÀÀ» º¸¿´À¸³ª, 1ÁÖ 2ÁÖ ¹× 4ÁÖ Á¶Á÷¼Ò°ß¿¡¼­´Â Å« Â÷ÀÌ°¡ ¾ø¾ú´Ù.
3. 1:5 Èñ¼® formocresol ½ÇÇ豺ÀÇ °æ¿ì Ÿ±º¿¡ ºñÇÏ¿© 1ÀÏ, 1ÁÖ, 2ÁÖ ¹× 4ÁÖ Á¶Á÷ ¼Ò°ß¿¡¼­
¸Å¿ì ½ÉÇÑ ¿°Áõ¼Ò°ßÀ» º¸¿´´Ù.
4. Glutaraldehyde ½ÇÇ豺°£ÀÇ ¿°ÁõÁ¤µµ°¡ º°´Ù¸¥ Â÷À̸¦ º¸ÀÌÁö ¾Ê´Â °ÍÀ¸·Î ¹Ì·ç¾î, ÇöÀç
ÀÓ»ó¿¡¼­ ÀûÁ¤ ³óµµ·Î ÃßõµÇ´Â 2%ÀÇ »ç¿ë¿¡ Àǹ®ÀÌ Á¦±âµÇ¸ç º¸´Ù °í³óµµÀÇ ÀÓ»óÀû¿ëÀÌ
°í·ÁµÉ °¡´É¼ºÀ» ½Ã»çÇÏ°í ÀÖ´Ù.
#ÃÊ·Ï#
Tissue irritation potential of several pulpotomy medicaments(2, 5, 10% glutaraldehyde
and 1 : 5 diluted formocresol) during various time intervals(1, 7, 14, 28 days) in sixteen
Sprague-Dawley rats were evaluated histologically under light microscope.
No significant differences in the degree of irritation could be found between 2, 5, and
10% glutaraldehyde groups, except 1 day-10% glutaraldehyde group which showed
higher inflammatory response than other 1 day-glutaraldehyde groups.
Specimens of 1 : 5 diluted formocresol groups were shown to be highly irritating to
connective tissues in general and the inflammatory responses persisted through out the
whole test periods.
From the results of the present study, the clinical application of 2% glutaraldehyde
being recommended as an adequate concentration might be reconsidered and the possible
use of higher concentration could be thought.

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